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Can you take Xanax while taking Benadryl?

There are some side effects that you might experience when combining these two drugs, including increased drowsiness and slowed breathing. These side effects can be dangerous if they are severe enough, so you should avoid taking these medications together if at all possible.

Xanax is an anti-anxiety medication that works by affecting chemicals in your brain called neurotransmitters, which allow communication between the cells of your brain. It is used to treat anxiety disorders and panic attacks, as well as insomnia. You should not take Xanax without a prescription from a doctor or if you have been abusing other substances such as alcohol or narcotics.

Benadryl is an over-the-counter antihistamine that relieves symptoms of allergies such as runny nose, sneezing and itchy eyes caused by pollen or pet dander by blocking histamine in your body which triggers allergy symptoms when released into your bloodstream during an allergic reaction. It also helps relieve symptoms of motion sickness caused by movement of high altitudes such as airplanes or boats.

Xanax and Benadryl 

Xanax and Benadryl are both medications used to treat anxiety, but they work in different ways.

Benadryl is a sedative which can help you relax and fall asleep. It does this by blocking histamine receptors in your brain, which are responsible for the release of neurotransmitters that cause feelings of anxiety and agitation. Xanax is a benzodiazepine which acts as an anti-anxiety medication by increasing the activity of GABA receptors in the brain. By doing so, it slows down the activity of neurons and allows them to function more normally.

Many people wonder if it’s safe to take Benadryl with Xanax because these two drugs have opposite effects on your body—Benadryl makes you drowsy while Xanax makes you feel more awake. However, there are no significant risks associated with taking these two medications together as long as they are taken at different times in the day (i.e., not at the same time).


When taken together, Xanax and Benadryl can cause drowsiness or sleepiness. If you’re taking both of these drugs to treat anxiety, this could be problematic because anxiety is often characterized by being tense or awake.

It’s also important to note that Benadryl can cause drowsiness even when taken on its own. So if you’re taking it just for allergies or other purposes, be aware that it could make you sleepy while driving or operating machinery.

Benadryl and Xanax: A Deadly Combination

In fact, the combination of Benadryl and Xanax can be fatal because it increases levels of serotonin, an important chemical in the brain that helps regulate mood and sleep cycles.

When these drugs are combined, they can cause serotonin syndrome—a disorder characterized by high fever, confusion or disorientation, muscle rigidity (including stiffness in the neck), shivering or tremors, sweating or clamminess, nausea or vomiting, diarrhea or loose stools (or both), fast heart rate (tachycardia) or irregular heart rhythm (arrhythmia).

The risk of death from taking these drugs together is higher for people who have heart disease or other conditions that affect blood flow through the body; those who take more than one type of sedative-hypnotic drug; and those who consume alcohol while taking these medications.

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